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Indications and tips for the use of HSC for the treatment of IBD launched in 1995 by an international committee on four important criteria: (1) indestructibility to immunosuppressive treatment.; (2) the persistence of pathological conditions identified with endoscopy, colonoscopy, or magnetic resonance enterography; (3) patients who have undergone an upcoming surgical intervention with a excellent risk of developing short bowel syndrome or refractory colon disease; and 4) patients who refused therapy of persistent perianal lesions by coloproctectomy with definitive stroma implantation..28 in compliance with standard procedure, proprietary HSCs are using cyclophosphamide, which is combined with granulocyte colony stimulating factor (g-csf), http://jet-links.com/9-Benefits-of-Stem-Cell-Therapy-that-You-should-to-Know-about_372782.html in two different concentrations (4 g/m2 and 2 g/m2).